产品名称
单克隆抗 CD28 小鼠抗, low endotoxin, clone CD28.2, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
CD28.2, monoclonal
form
buffered aqueous solution
species reactivity
nonhuman primates, human
concentration
1 mg/mL
technique(s)
flow cytometry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CD28(940)
Application
试剂设计用于流式细胞术分析。流式细胞术的建议工作稀释度为 2-8μg/mL样品。使用本品的推荐起始点是指定稀释度。研究者应确定工作浓度。
Biochem/physiol Actions
分化簇28（CD28）抗原在T细胞活化、增殖、存活和功能中起作用。它介导胸腺发育、外周稳态（peripheral homeostasis）和调节性T细胞的抑制功能。CD28在信号转导中起作用，并参与许多接头蛋白（adaptor protein）的活化。该基因的突变增加了类风湿性关节炎的患病风险。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
完全放心地试用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多。
General description
分化簇 28 (CD28) 抗原是一种在初始 T 细胞中表达的共刺激受体（co-stimulatory receptor ）。它含有一个短的细胞质尾和两个富含脯氨酸的基序。CD28 由定位于人类染色体 2q33.2 的基因编码。
Immunogen
DC28.1.3.3 杂交瘤细胞
Physical form
溶于不含叠氮化物的磷酸盐缓冲盐水 (pH 7.4) 中；0.2 μm 过滤器灭菌。通过 LAL 试验测定，内毒素水平低于 10 EU/mg 蛋白。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Genetic variants at CD28, PRDM1, and CD2/CD58 are associated with rheumatoid arthritis risk
Raychaudhuri S
Nature Genetics, 41, 1313-1318 (2009)
CTLA-4 and Not CD28 Is a Susceptibility Gene for Thyroid Autoantibody Production
Tomer Y
The Journal of Clinical Endocrinology and Metabolism, 86, 1687-1693 (2001)
Interrupting CD28 costimulation before antigen rechallenge affects CD8(+) T-cell expansion and effector functions during secondary response in mice.
Frohlich M
European Journal of Immunology, 46, 1644-1655 (2016)
Yuki Akieda et al.
Journal of immunology (Baltimore, Md. : 1950), 194(9), 4162-4174 (2015-04-01)
In patients receiving allogeneic hematopoietic cell transplantation, chronic graft-versus-host disease (cGVHD) remains a frequent complication and resembles autoimmune diseases such as systemic lupus erythematosus and systemic sclerosis. Our previous work demonstrated the critical role of CD28 costimulation of donor T
Cheryl H Rozanski et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4717-4728 (2015-04-03)
In health, long-lived plasma cells (LLPC) are essential for durable protective humoral immunity, and, conversely, in disease are a major source of pathogenic Abs in autoimmunity, graft rejection, and allergy. However, the molecular basis for their longevity is largely unknown.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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