产品名称
Monoclonal Anti-CD11c-APC antibody produced in mouse, clone BU15, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
Allophycocyanin conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
BU15, monoclonal
form
buffered aqueous solution
species reactivity
human, monkey, canine
technique(s)
flow cytometry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ITGAX(3687)
Application
The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (1 mL) is sufficient for 100 tests.
Biochem/physiol Actions
Cluster of differentiation 11c (CD11c) delivers co-stimulatory signals to activated lymphocytes. Elevated expression of the gene decreased the risk of death and relapse in gastric cancer (GC) patients. The protein can be considered as an alternative prognosis marker for GC. Overexpression of CD11c in CD8+ cells might lead to the development of Behcet′s disease (BD).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Cluster of differentiation 11c (CD11c), also known as integrin subunit α X (ITGAX), is an antigen receptor, encoded by the gene mapped to human chromosome 16p11.2. The encode protein belongs to the adhesion molecule integrin family and is mainly expressed in natural killer cells, macrophages and even some activated B and T cells.
The antibody BU15 reacts with CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages.
Immunogen
Dendritic cells of synovial fluid
Physical form
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
The integrins
Takada Y
Genome Biology, 8 (2007)
High expression of CD11c indicates favorable prognosis in patients with gastric cancer
Wang Y
World Journal of Gastroenterology, 21, 9403-9412 (2015)
CD11c is upregulated in CD8+ T cells of patients with Behcet's disease.
Park YJ
Clinical and Experimental Rheumatology, 34, S86-S91 (2016)
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