SAB4700423
单克隆抗 CD326 小鼠抗
clone VU-1D9, purified immunoglobulin, buffered aqueous solution
别名:
抗 EPCAM
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
VU-1D9, monoclonal
Application:
western blot
Species reactivity:
human
Citations:
8
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
单克隆抗 CD326 小鼠抗, clone VU-1D9, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
VU-1D9, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/mL
technique(s)
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... EPCAM(4072)
Application
建议的免疫印迹工作稀释度为1-4 μg / mL样品。建议使用指示稀释剂来使用该产品。工作浓度应由研究员确定。
Biochem/physiol Actions
上皮细胞粘附分子 （EpCA，CD326）是一种跨膜糖蛋白，参与多种细胞功能，如上皮特异性细胞间细胞粘附、细胞信号转导、迁移、增殖和分化。EpCAM是位于人结肠癌的主要表面抗原。它具有成为多种癌症（包括上皮性卵巢癌（EOC））诊断标志物的潜力。EpCAM被认为是癌症治疗的潜在靶点。在wnt信号转导途径成分的协助下，EpCAM在干细胞信号传导中起关键作用。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
完全放心地试用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多。
General description
上皮细胞粘附分子 （EpCAM）或称分化簇326（CD326）由位于人类染色体 2p21的14 kb GA733-2基因编码。人EpCAM的表达限于结肠、小肠、肺、肾脏、胸腺、肝脏、胰腺和胃的上皮细胞。它也在多种癌症、祖细胞和干细胞中表达。CD326 是一种跨膜糖蛋白，其特征在于含有一个胞外区（ectodomain）、一个跨膜结构域和一个含26个残基的胞质结构域。
鼠单克隆抗体VU-1D9可识别上皮细胞系标志物CD326/EpCAM的EGF样结构域I内的表位。该抗体可强烈染色各种正常上皮细胞和癌。
Immunogen
小细胞肺癌细胞系 H69
Physical form
溶于磷酸盐缓冲盐水，pH 7.4，含有15 mM 叠氮化钠。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Luojun Chen et al.
Scientific reports, 8(1), 1188-1188 (2018-01-21)
Circulating tumor cells (CTCs) provide a new approach for auxiliary diagnosis, therapeutic effect evaluation, and prognosis prediction for cancer patients. The epithelial cell adhesion molecule (EpCAM)-based separation method (CellSearch) showed good clinical use in multiple types of cancer. Nevertheless, some
Chikako Zen et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 17(8), 943-954 (2011-04-15)
We investigated the phenotype of hepatocellular carcinoma (HCC) in livers removed during transplantation after local ablation therapy by transarterial chemoembolization (TACE). This study involved 80 HCC nodules (40 treated with TACE and 40 not treated with local ablation before transplantation)
Na Li et al.
Cancer management and research, 11, 10939-10948 (2020-02-06)
Circulating tumor cell (CTC) detection methods based on epithelial cell adhesion molecule (EpCAM) have low detection rates in epithelial ovarian cancer (EOC). Meanwhile, folate receptor alpha (FRα) has high expression in EOC cells. We explored the feasibility of combining FRα
Gilbert Spizzo et al.
Gynecologic oncology, 103(2), 483-488 (2006-05-09)
Currently available clinical and molecular factors provide still an insufficient prognostic and predictive assessment for patients with epithelial ovarian cancer (EOC). To identify a potential molecular target and prognostic/predictive factor for EOC, we investigated in a retrospective study the prognostic
Graham Carpenter et al.
Cancer cell, 15(3), 165-166 (2009-03-03)
The epithelial-specific cell adhesion molecule (EpCAM) modulates cell adhesion and proliferation. Its overexpression correlates with tumor cell proliferation, and EpCAM is a therapeutic target. In the February issue of Nature Cell Biology, Maetzel et al. demonstrate that proliferative responses to
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