SAB4700672
Monoclonal Anti-KRT18-FITC antibody produced in mouse
clone DC-10, purified immunoglobulin, buffered aqueous solution
别名:
Anti-Cytokeratin 18
生物来源
mouse
质量水平
偶联物
FITC conjugate
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
DC-10, monoclonal
表单
buffered aqueous solution
种属反应性
human
浓度
0.1 mg/mL
技术
flow cytometry: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... KRT18(3875)
相关类别
一般描述
Keratin 18/cytokeratin 18 (CK18) is a structural protein. It is present in single-layer epithelia. It is located on human chromosome 12q13.
The antibody DC-10 reacts with Cytokeratin 18 (45 kDa). Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues.
免疫原
Human breast carcinoma cell line PMC-42
应用
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 5-10 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
生化/生理作用
Keratins help to maintain the structural integrity. They also control Fas‐mediated apoptosis and regulate cell size and protein synthesis. Keratin 18 plays a major role in the development of lung cancer. It acts as a therapeutic target for non-small cell lung cancer (NSCLC).
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Characterization of New Members of the Human Type II Keratin Gene Family and a General Evaluation of the Keratin Gene Domain on Chromosome 12q13.13
Rogers MA
The Journal of Investigative Dermatology, 124, 536-544 (2005)
Cytokeratin 18 knockdown decreases cell migration and increases chemosensitivity in non-small cell lung cancer.
Zhang B
Journal of Cancer Research and Clinical Oncology, 142, 2479-2487 (2016)
Ricardo Rodrigues-Pinto et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 34(8), 1327-1340 (2016-02-26)
In humans, the nucleus pulposus (NP) is composed of large vacuolated notochordal cells in the fetus but, soon after birth, becomes populated by smaller, chondrocyte-like cells. Although animal studies indicate that notochord-derived cells persist in the adult NP, the ontogeny
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