SAB4700755
Monoclonal Anti-CD82 antibody produced in mouse
clone C33, purified immunoglobulin, buffered aqueous solution
别名:
4F9, C33, IA4, R2, Anti-KAI1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
C33, monoclonal
Application:
FUNC
flow cytometry
immunoblotting
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
flow cytometry
immunoblotting
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
Species reactivity:
human
Citations:
2
Technique(s):
FUNC: suitable
flow cytometry: suitable
immunoblotting: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
flow cytometry: suitable
immunoblotting: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
Uniprot accession no.:
产品名称
Monoclonal Anti-CD82 antibody produced in mouse, clone C33, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
C33, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/mL
technique(s)
FUNC: suitable
flow cytometry: suitable
immunoblotting: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CD82(3732)
Biochem/physiol Actions
The cluster of differentiation 82 (CD82)/Kangai 1 (KAI1) protein is a metastasis suppressor. It inhibits the migration and invasion of cancer cells. CD82 plays a key role in cell adhesion, fusion, apoptosis, and morphogenesis. CD82 can mobilize intracellular Ca2+ in lymphocytes. It acts as an accessory molecule in the activation of the T-cell. CD82 has an inhibitory role in syncytium formation caused by the human T-cell leukemia virus in immune cells (HTLV). Lower expression of CD82 is observed in several cancers, including prostate and lung cancer.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
The cluster of differentiation 82 (CD82)/Kangai 1 (KAI1), a type III transmembrane protein, is a member of the tetraspanin superfamily. It has four putative transmembrane domains and one small and one large extracellular loop. CD82 is widely expressed in normal tissues. Its mRNA is seen at high levels in the spleen, placenta, lung, liver, kidney, and prostate. CD82 was previously identified as lymphocyte cell-surface protein. The KAI1/CD82 gene is mapped to human chromosome 11p11.2.
Immunogen
C91/PL (human HTLV-1+ T cell line)
Physical form
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Hélène Tonoli et al.
Trends in molecular medicine, 11(12), 563-570 (2005-11-08)
The transmembrane glycoprotein CD82 is a member of the tetraspanin protein family and is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion and migration to apoptosis and cell-morphology alterations. Downregulation of CD82 expression is associated with the
Wei M Liu et al.
Cancer letters, 240(2), 183-194 (2005-11-02)
Tetraspanin KAI1/CD82 is a wide-spectrum tumor metastasis suppressor. KAI1/CD82 suppresses tumor metastasis by primarily inhibiting cancer cell motility and invasiveness. In tetraspanin-enriched microdomain, KAI1/CD82 associates with the proteins important for cell migration such as cell adhesion molecule, growth factor receptor
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