conjugate
unconjugated
antibody product type
primary antibodies
clone
MHD4-46, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/ml
technique(s)
FUNC: suitable
flow cytometry: suitable
isotype
IgG1κ
UniProt accession no.
storage temp.
2-8°C
target post-translational modification
unmodified, unmodified
Quality Level
Gene Information
human ... DLL4(54567)
Biochem/physiol Actions
The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.
General description
DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.
Immunogen
recombinant soluble human DLL4
Other Notes
The antibody solution should be gently mixed before use.
Physical form
Phosphate buffered saline (PBS), pH 7.4
Preparation Note
Purified by protein-A affinity chromatography.
Store at 2-8°C. Do not freeze.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
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