Monoclonal Anti-CACNA1D antibody produced in mouse

Monoclonal Anti-CACNA1D antibody produced in mouse has been used in immunocytochemistry.

Calcium channel, L type α-1 polypeptide isoform 2 (CACNA1D) is crucial for the functioning of the brain and in hearing. It gets activated at a fast rate and withstands high inward Ca²⁺ currents even at threshold voltages. CACNA1D aids in dendritic signals linked to mitochondrial stress in the brain and is important for estrogen-stimulated Ca²⁺ influx. Studies have shown that in atrial myocytes, the C terminus of the channel translocates to the nucleus and regulates Ca²⁺-activated K⁺ channels. CACNA1D was shown to be upregulated in endometrial cancer and its knockdown showed a reduction in cell proliferation in vitro. Mutations in the gene encoding it has been associated with aldosterone-producing adenomas (APAs), where it leads to the formation of small adenomas.

Detects ~250 kDa. No cross-reactivity against Cav1.2

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Calcium channel, L type α-1 polypeptide isoform 2 (CACNA1D) is expressed in many tissues and possesses six transmembrane segments, along with a loop lining the pore of the channel. The gene encoding CACNA1D is localized on human chromosome 3p14.3.

Fusion protein amino acids 859-875 of rat Cav1.3, Accession Number P27732

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide