SAB5200055
Monoclonal Anti-KCNB1 antibody produced in mouse
clone S4-11, 1 mg/mL, purified immunoglobulin
别名:
Anti-DRK1PC, Anti-Kcnb1, Anti-Kcr1-1, Anti-Kv2.1, Anti-Kv2.1, S4-11, Anti-Shab
产品名称
Monoclonal Anti-KCNB1 antibody produced in mouse, clone S4-11, 1 mg/mL, purified immunoglobulin
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
S4-11, monoclonal
form
buffered aqueous glycerol solution
mol wt
antigen predicted mol wt 105-125 kDa
species reactivity
human, mouse, rat, monkey
concentration
1 mg/mL
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
rat ... Kcnb1(25736)
Biochem/physiol Actions
Detects ~105-125 kDa. Recognizes the Shab related α-subunit Kv2.1.
Potassium voltage-gated channel subfamily B member 1 (KCNB1) plays a vital role in hippocampal neuron excitation homeostasis. The encoded protein is mainly implicated in the generation of the major delayed rectifier potassium current in pyramidal neurons. Mutation in the gene is associated with the development of left ventricular (LV) hypertrophy and early-onset infantile epilepsy in humans.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
The potassium voltage-gated channel subfamily B member 1 (KCNB1) gene is mapped to human chromosome 20q13.13. This gene codes for a α subunit of voltage-gated potassium Kv2.1 channel. The encoded protein contains 858 amino acids and six transmembrane segments (S1–S6). KCNB1 is mainly expressed in the central nervous system, but at high level in somatodendritic compartment of neocortical and pyramidal neurons.
Immunogen
Bacterially expressed GST Bacterially expressed GSTfusion protein corresponding toamino acids 509-853 of rat KV2.1, Accession Number NM_004975.
Physical form
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: The HyperGEN Study
Arnett DK
BMC Medical Genetics (2009)
Novel KCNB1 mutation associated with non-syndromic intellectual disability
Latypova X
Journal of Human Genetics, 62, 569-573 (2017)
De novo KCNB1 mutations in infantile epilepsy inhibit repetitive neuronal firing
Saitsu H
Scientific Reports (2015)
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