SAB5200113
Anti-Amyloid Precursor Protein (APP) Antibody
rabbit polyclonal
别名:
Anti-A11, Anti-Amyloid Oligomer αβ, Anti-Amyloid Oligomers (A11)
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UNSPSC Code:
12352203
NACRES:
NA.41
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
immunoprecipitation (IP)
indirect ELISA
indirect immunofluorescence
western blot
immunoprecipitation (IP)
indirect ELISA
indirect immunofluorescence
western blot
Species reactivity:
mouse, eukaryotes, rat, human
Citations:
10
Technique(s):
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-APP antibody produced in rabbit, 1 mg/mL, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
mouse, eukaryotes, rat, human
concentration
1 mg/mL
technique(s)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... APP(351)
Physical form
PBS, 50% glycerol, and 0.09% sodium azide
Application
Anti-APP antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Amyloid β precursor protein (APP) regulates cell signaling. Mutation in this gene is associated with Alzheimer′s disease. It is implicated in synaptic plasticity, dendritic morphogenesis and neuroprotection. APP modulates synaptic vesicle proteins and synaptic transmission. It is involved in GABAergic transmission and maintains the excitatory/inhibitory (E/I) balance.
Amyloid precursor protein (APP) plays a key role in Wnt signalling. It helps to increase synaptoxicity, that is facilitated by Dickkopf-1 (Dkk1). Mutations on this gene results in autosomal dominant early-onset Alzheimer disease (ADEOAD)/hereditary dementia with cerebral amyloid angiopathy (CAA).
Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Amyloid β precursor protein (APP) is a type 1 transmembrane protein. The gene is located on human chromosome 21q21.3.
Immunogen
Synthetic molecular mimic of soluble oligomers.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Human brain-derived Abeta oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP
Wang Z, et al.
The Journal of Neuroscience, 37(49), 11947-11966 (2017)
Novel derivative of Paeonol, Paeononlsilatie sodium, alleviates behavioral damage and hippocampal dendritic injury in Alzheimer's disease concurrent with cofilin1/phosphorylated-cofilin1 and RAC1/CDC42 alterations in rats
Han F, et al.
PLoS ONE, 12(9), e0185102-e0185102 (2017)
Human brain-derived Abeta oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP
Wang Z, et al.
The Journal of Neuroscience, 8(1), 11947-11966 (2017)
Fei Han et al.
PloS one, 12(9), e0185102-e0185102 (2017-09-22)
Alzheimer's disease (AD) is a typical hippocampal amnesia and the most common senile dementia. Many studies suggest that cognitive impairments are more closely correlated with synaptic loss than the burden of amyloid deposits in AD progression. To date, there is
A role for APP in Wnt signalling links synapse loss with beta-amyloid production
Elliott C, et al.
Translational Psychiatry, 8(1), 179-179 (2018)
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