SAB5200898
Monoclonal Anti-Glun2A/Nr2A - Apc antibody produced in mouse
clone S327-95, purified immunoglobulin
别名:
Anti-GRIN2A, Anti-HNR2A, Anti-NMDA 2A
产品名称
Monoclonal Anti-Glun2A/Nr2A - Apc antibody produced in mouse, clone S327-95, purified immunoglobulin
biological source
mouse
conjugate
Allophycocyanin conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
S327-95, monoclonal
form
buffered aqueous solution
mol wt
antigen predicted mol wt 170 kDa
species reactivity
human, rat, mouse
concentration
1 mg/mL
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
rat ... Grin2a(24409)
Biochem/physiol Actions
The GRIN2A (glutamate ionotropic receptor NMDA (N-methyl-D-aspartate) type subunit 2A) gene is associated with focal epilepsy and impaired speech. NMDA glutamate receptor α2 subunit is involved in neuron development, maintains synaptic plasticity and is associated with memory. GRIN2A is related to schizophrenia and Alzheimer′s disease. Mutations in GRIN2A gene upregulates NMDA action and might lead to melanoma tumors. NMDA participates in apoptosis and proliferation of cancer cells.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
The GRIN2A (glutamate ionotropic receptor NMDA (N-methyl-D-aspartate) type subunit 2A) gene is mapped to human chromosome 16p13.2. It codes for a transmembrane ligand-gated ion channel called N-methyl-D-aspartate glutamate receptor α2 subunit.
Immunogen
Fusion protein amino acids 75-325 (extracellular N-terminus) of rat GluN2A/NR2A
Physical form
PBS pH7.4, 50% glycerol, 0.09% sodium azide
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency-molecular profiling and functional rescue
Addis L, et al.
Scientific Reports, 7(1), 66-66 (2017)
Selected GRIN2A mutations in melanoma cause oncogenic effects that can be modulated by extracellular glutamate
Dmello SAN, et al.
Cell Calcium, 60(6), 384-395 (2016)
2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor
Gorska PM, et al.
Journal of Cellular Physiology, 232(11), 3030-3049 (2017)
GRIN2A mutations in epilepsy-aphasia spectrum disorders
Yang X, et al.
Brain & Development, 40(3), 205-210 (2018)
Epilepsy in patients with GRIN2A alterations: genetics, neurodevelopment, epileptic phenotype and response to anticonvulsive drugs
von Stupnagel C, et al.
European Journal of Paediatric Neurology, 21(3), 530-541 (2017)
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