SAB5200921
Monoclonal Anti-Notch1 - Percp antibody produced in mouse
clone S253-32, purified immunoglobulin
别名:
Anti-Motch, Anti-Neurogenic locus notch homolog protein 1, Anti-Neurogenic locus notch protein homolog, Anti-TAN1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
Peridinin-Chlorophyll-Protein Complex
Clone:
S253-32, monoclonal
Application:
ICC, WB
Citations:
5
biological source
mouse
conjugate
Peridinin-Chlorophyll-Protein Complex
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
S253-32, monoclonal
form
buffered aqueous solution
mol wt
antigen predicted mol wt >270, ~120 kDa
species reactivity
mouse, rat, human
concentration
1 mg/mL
technique(s)
immunocytochemistry: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Notch1(18128)
General description
The NOTCH1 gene is mapped to human chromosome 9q34.3. In mice, Notch1 is highly expressed in immature neurons of hippocampus. Notch1 is localized to renal epithelial cells and podocytes of metanephros.
Immunogen
Fusion protein amino acids 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1
Biochem/physiol Actions
The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Notch signaling pathway is involved in the development and progress of cardiovascular diseases. Notch1 function is predominant in developing kidney compared to compared to the mature organ.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling.
Zhang C, et al.
Journal of Cellular and Molecular Medicine, 21(7), 1315-1328 (2017)
Phospholipase Cγ1 Mediates Intima Formation Through Akt?Notch1 Signaling Independent of the Phospholipase Activity.
Jiang D, et al.
Journal of the American Heart Association, 6(7), e005537-e005537 (2017)
Postnatal dysregulation of Notch signal disrupts dendrite development of adult-born neurons in the hippocampus and contributes to memory impairment.
Ding X F, et al.
Scientific Reports, 6, 25780-25780 (2016)
Evolutionary significance of intra-genome duplications on human chromosomes.
Endo T, et al.
Gene, 205(1), 19-27 (1997)
Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway
Xu J, et al.
American Journal of Physiology. Cell Physiology, 296(3), C535-C543 (2009)
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