SAB5201187
Monoclonal Anti-Lrrk2/Dardarin - Biotin antibody produced in mouse
clone S231B-34, purified immunoglobulin
别名:
Anti-Dardarin, Anti-Leucine-rich repeat kinase 2, Anti-PARK8, Anti-RIP7
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
biotin conjugate
Clone:
S231B-34, monoclonal
Application:
ICC, IHC, WB
Citations:
3
biological source
mouse
conjugate
biotin conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
S231B-34, monoclonal
form
buffered aqueous solution
mol wt
antigen predicted mol wt 200 kDa
species reactivity
human, rat
concentration
1 mg/mL
technique(s)
immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LRRK2(120892)
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General description
Leucine rich repeat kinase 2 (LRRK2) is a large protein containing protein-protein interaction region enclosing two main domains for : central kinase and GTPase.
Immunogen
Fusion protein amino acids 841-960 of human LRRK2. 81% identical in mouse, 80% identical in rat. <30% identity with LRRK1.
Biochem/physiol Actions
Mutation in the leucine rich repeat kinase 2 (LRRK2) gene causes familial Parkinson′s disease (PD) and sporadic PD. Mitochondrial dysfunction is observed as a result of LRRK2 gene variation.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Case-control analysis of leucine-rich repeat kinase 2 protective variants in Alzheimer's disease
Ng ASL, et al.
Neurobiology of Aging, 64, 157-e7-157-e7 (2018)
LRRK2 mediated Rab8a phosphorylation promotes lipid storage
Yu M, et al.
Lipids in Health and Disease, 17(1), 34-34 (2018)
Decreased sirtuin deacetylase activity in LRRK2 G2019S iPSC-derived dopaminergic neurons
Schwab AJ, et a.
Stem Cell Reports, 9(6), 1839-1852 (2017)
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