SAB5201735
Monoclonal Anti-Tcp1 Alpha - Atto 390 antibody produced in rat
clone 23c, purified immunoglobulin
别名:
Anti-AI528772, Anti-Ccta, Anti-Tric, Anti-p63
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
Atto 390 conjugate
Clone:
23c, monoclonal
Application:
ICC, IF, IP, WB
Citations:
4
biological source
rat
conjugate
Atto 390 conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
23c, monoclonal
form
buffered aqueous solution
mol wt
antigen predicted mol wt 60 kDa
species reactivity
mouse, human, dog, rabbit, rat, hamster, bovine, sheep
concentration
1 mg/mL
technique(s)
immunocytochemistry: suitable, immunofluorescence: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG2c
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Tcp1(21454)
General description
Tcp1 (t-complex protein ) is a chaperonin and a ATPase complex that encodes a chaperonin, localized to the cytosol.
Immunogen
Purified recombinant mouse TCP1 alpha construct encoding the C-terminal half of the 1.8 kb full-length Tcp 1b gene expressed in E. coli. Detects the COOH group.
Biochem/physiol Actions
Tcp1 (t-complex protein) is involved in protein folding mechanism of essential proteins such as actins, tubulin, cyclin E, α-transducin and von Hippel Lindau protein. Tcp1 participates in synthesis of proteins that make up the cytoskeleton and thus involved in cellular processes such as chromosome segregation, cell migration, and intracellular transport. Increased TCP1 gene expression is observed in cancer and upregulation elevates with the disease progression.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
The molecular chaperone CCT modulates the activity of the actin filament severing and capping protein gelsolin in vitro.
Svanstrom A and Grantham J
Cell Stress & Chaperones, 21(1), 55-62 (2016)
TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington?s disease.
Zhao X, et al.
Proceedings of the National Academy of Sciences of the USA, 113(38), E5655-E5664 (2016)
Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis.
Jiang X, et al.
Oncotarget, 6(39), 42105-42105 (2015)
Satyabrata Sinha et al.
Investigative ophthalmology & visual science, 55(6), 3775-3785 (2014-05-24)
While some evidence suggests an essential role for the chaperonin containing t-complex protein 1 (CCT) in ciliogenesis, this function remains poorly understood mechanistically. We used transgenic mice, previously generated in our lab, and characterized by a genetically-induced suppression of CCT
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