产品名称
Anti-CD25 antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP176, affinity isolated antibody
biological source
rabbit
recombinant
expressed in proprietary host
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
SP176, monoclonal
species reactivity
human (tested)
species reactivity (predicted by homology)
rat, mouse
technique(s)
immunohistochemistry: 1:100
western blot: 1:200
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... IL2RA(3559)
Biochem/physiol Actions
Interleukin-2 (IL-2) is a cytokine that is essential in modulating activation, proliferation, and survival of several T-cell subsets. IL2RA gene has been associated with susceptibility to multiple sclerosis (MS).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
IL2RA (interleukin 2 receptor subunit α) gene codes for interleukin-2 receptor α-chain CD25. CD25 is expressed on activated T-cells. The activated T-cells liberate this molecule in the form of a soluble variant (referred to as soluble IL-2 receptor; sIL-2R) from the cell membrane into the circulation. The CD25 gene is located on human chromosome 10p15. The gene spans a length of 48kb with eight exons.
Interleukin-2 receptor subunit alpha, also known as CD25, is a type I transmembrane protein and the alpha chain of the IL-2 receptor. CD25 and CD122 form a heterodimer to act as a high-affinity receptor for IL-2. CD25 is expressed on activated T cells, activated B cells, some thymocytes, myeloid precursors, oligodendrocytes, and most B cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, and tumor infiltrating lymphocytes.
Immunogen
Synthetic peptide derived from the C-terminus of human CD25 protein.
Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Eileen Shiuan et al.
Cancers, 13(6) (2021-04-04)
Predicting response to ICI therapy among patients with renal cell carcinoma (RCC) has been uniquely challenging. We analyzed patient characteristics and clinical correlates from a retrospective single-site cohort of advanced RCC patients receiving anti-PD-1/PD-L1 monotherapy (N = 97), as well
Relationship between soluble CD25 and gene expression in healthy individuals and patients with multiple sclerosis.
Buhelt S, et al.
Cytokine, 93, 15-25 (2017)
Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes?
Bharwani KD, et al.
Mediators of Inflammation, 2017, 2764261-2764261 (2017)
Toward further mapping of the association between the IL2RA locus and type 1 diabetes.
Qu H Q, et al.
Diabetes, 56(4), 1174-1176 (2007)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持