SAB5500057
Anti-CD3 antibody, Rabbit monoclonal
recombinant, expressed in proprietary host, clone SP162, affinity isolated antibody
别名:
Anti-CD3epsilon, Anti-IMD18, Anti-T3E, Anti-TCRE
产品名称
Anti-CD3 antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP162, affinity isolated antibody
biological source
rabbit
recombinant
expressed in proprietary host
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
SP162, monoclonal
species reactivity
human (tested)
species reactivity (predicted by homology)
rat, chicken, rabbit, mouse, pig, bovine, dog
technique(s)
flow cytometry: 1:150
immunoblotting: 1:150
immunohistochemistry: 1:150
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CD3E(916)
Application
Anti-CD3 antibody, Rabbit monoclonal has been used in immunohistochemistry.
Biochem/physiol Actions
CD3E (CD3e molecule) gene is associated with actin cytoskeletal rearrangement, through activation of a number of signaling pathways. CD3E is essential for membrane binding of T-cell regulator (TCR) protein complex.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
CD3E (CD3e molecule) gene is mapped to human chromosome 11q23.3. This gene encodes fora subunit of T-cell regulator (TCR) protein complex. It possesses IgG (immunoglobulin G)-like extracelluar domain at the N-terminal, a transmembrane domain, a peptide bridge and an immunoreceptor tyrosine-based activation motif (ITAM) towards the cytoplasm. The protein also contains basic residue-rich sequence (BRS).
This antibody reacts with the intracytoplasmic portion of the CD3 antigen expressed by T cells. It stains human T cells in both the cortex and medulla of the thymus and in peripheral lymphoid tissues. This antibody is suitable for staining normal and neoplastic T cells in formalin-fixed, paraffin-embedded tissues.
Immunogen
Synthetic peptide corresponding to internal region of the epsilon chain of human CD3 protein.
Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Evidence for inducible recruitment of Wiskott-Aldrich syndrome protein to T cell receptor-CD3 complex in Jurkat T cells
Paensuwan P, et al.
Asian Pacific Journal of Allergy and Immunology / Launched by the Allergy and Immunology Society of Thailand, 33(3) (2015)
SnapShot: forkhead transcription factors II
Tuteja G and Kaestner KH
Cell, 131(1), 192-192 (2007)
Ionic CD3- Lck interaction regulates the initiation of T-cell receptor signaling
Li L, et al.
Proceedings of the National Academy of Sciences of the USA, 114(29), E5891-E5899 (2017)
Xuan He et al.
Cell, 184(13), 3467-3473 (2021-06-17)
We previously reported that a single immunization with an adenovirus serotype 26 (Ad26)-vector-based vaccine expressing an optimized SARS-CoV-2 spike (Ad26.COV2.S) protected rhesus macaques against SARS-CoV-2 challenge. To evaluate reduced doses of Ad26.COV2.S, 30 rhesus macaques were immunized once with 1 ×
The progression of CD56+ myeloid sarcoma: A case report and literature review
Wang X, et al.
Oncology Letters, 11(5), 3091-3096 (2016)
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