产品名称
Anti-PU.1 antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP238, affinity isolated antibody
biological source
rabbit
recombinant
expressed in proprietary host
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
SP238, monoclonal
species reactivity
human (tested)
species reactivity (predicted by homology)
pig, rat, mouse
technique(s)
immunohistochemistry: 1:100
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SPI1(6688)
Biochem/physiol Actions
Spi-1 proto-oncogene (SPI1)/ PU.1 plays an essential role in myeloid development. It also acts as a transcription activator and is involved in macrophage proliferation. In addition, PU.1 along with other transcription factors, plays a vital role in fetal hematopoiesis. PU.1 controls cellular communication in the immune system. Thus, loss/reduced gene expression leads to loss of cellular communication, which in turn is associated with the development of leukemia.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
PU.1 is a transcription factor of the Ets family and activates target genes through the purine-rich PU-box. PU.1 plays an important role for the differentiation of myeloid cells and early B cell lymphocytes. PU.1 is overexpressed in some B cell lymphoma, Hodgkin, and non- Hodgkin lymphoma.
Spi-1 proto-oncogene (SPI1), also known as PU.1, is a mammalian transcription factor. It is encoded by the gene mapped to human chromosome 11p11.2. The encoded protein belongs to the E26 transformation specific (Ets) family of transcription factors. SPI1 is characterized with a C-terminal domain, an N-terminal transactivation domain and a central PEST domain involved in protein-protein interaction. The protein is mainly expressed in cells of the hematopoietic lineage such as macrophages, granulocytes and B lymphocytes.
Immunogen
Synthetic peptide derived from the internal region of the human PU.1 protein.
Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
The transcription factor PU. 1 is involved in macrophage proliferation.
Celada A, et al.
The Journal of Experimental Medicine, 184(1), 61-69 (1996)
Zebrafish SPI-1 (PU. 1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning.
Lieschke G J, et al.
Developmental Biology, 246(2), 274-295 (2002)
The transcription factor PU. 1 is a critical regulator of cellular communication in the immune system.
Turkistany S A, et al.
Archivum Immunologiae et Therapiae Experimentalis, 59(6), 431-440 (2011)
Role of PU. 1 in hematopoiesis.
Fisher R C and Scott E W
Stem Cells, 16(1), 25-37 (1998)
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