SAB5600004
Anti-Mouse IgG2c antibody, Rabbit monoclonal
recombinant, expressed in HEK 293 cells, clone RM223, purified immunoglobulin
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关于此项目
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
RM223, monoclonal, recombinant monoclonal
Application:
ELISA, ICC, IHC
Citations:
2
recombinant
expressed in HEK 293 cells
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
RM223, monoclonal, recombinant monoclonal
form
buffered aqueous glycerol solution
species reactivity
mouse
concentration
~1 mg/mL
technique(s)
ELISA: 0.01 μg/mL, immunoblotting: 0.5-2 μg/mL (non-reduced only), immunocytochemistry: 0.5-2 μg/mL, immunohistochemistry: 0.5-2 μg/mL
isotype
IgG
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
General description
IgG2c codes for Igh-1b. In mice, IgG2a and IgG2c are arranged in tandem on identical chromosome as two visible loci.
Immunogen
Purified mouse IgG2c whole molecule
Biochem/physiol Actions
Mouse IgG2c generate several unique non-bonded interactions between the BC, DE and FG loops than mIgG2b. It connects to FcγRIV (Fc γ receptor IV) with a high affinity in the complex-type glycoform. In mice, IgG2c has unique immune profiles like, response, immune-decoration, because of their difference in protein sequence.
This antibody reacts to the Fc region of mouse IgG2c. No cross reactivity with mouse IgG1, IgG2a, IgG2b, IgG3, IgM, IgA, IgE, human IgG, or rat IgG.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Possible allelic structure of IgG2a and IgG2c in mice.
Zhang Z, et al.
Molecular Immunology, 50(3), 169-171 (2012)
Mouse IgG2c Fc loop residues promote greater receptor-binding affinity than mouse IgG2b or human IgG1.
Daniel JF, et al.
PLoS ONE, 13(2), e0192123-e0192123 (2018)
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