SAB5700286
Anti-Phospho-CHEK1-S280 antibody produced in rabbit
别名:
CHEK1, CHK1
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NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
polyclonal
Species reactivity:
mouse, human, rat
Application:
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Technique(s):
immunofluorescence: 1:50-1:200
immunohistochemistry: 1:50-1:200
western blot: 1:200-1:2000
immunohistochemistry: 1:50-1:200
western blot: 1:200-1:2000
Citations:
Uniprot accession no.:
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
43
50
54
species reactivity
mouse, human, rat
concentration
1.66 mg/ml
technique(s)
immunofluorescence: 1:50-1:200
immunohistochemistry: 1:50-1:200
western blot: 1:200-1:2000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer280)
Quality Level
Gene Information
human ... CHEK1(1111)
General description
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
Immunogen
A synthetic phosphorylated peptide around S280 of human CHEK1 (NP_001265.2).
Physical form
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Preparation Note
Store at -20℃. Avoid freeze / thaw cycles.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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