SAB5701999
Anti-NCF4/p40-phox Antibody, clone 4L9Z4, Rabbit Monoclonal
别名:
NCF4, CGD3, NCF, P40PHOX, SH3PXD4, neutrophil cytosol factor 4
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NACRES:
NA.46
UNSPSC Code:
12352203
Species reactivity:
mouse
Technique(s):
immunohistochemistry: 1:50 - 1:200, immunoprecipitation (IP): 1:50 - 1:200, western blot: 1:500 - 1:2000
Application:
IHC, IP, WB
Citations:
-
species reactivity
mouse
concentration
0.8 mg/mL
technique(s)
immunohistochemistry: 1:50 - 1:200, immunoprecipitation (IP): 1:50 - 1:200, western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
LRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTRREFQREDIALNYRDAEGDLVRLLSDEDVALMVRQARGLPSQKRLFPWKLHITQKDNYRVYNTMP
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
biological source
rabbit
conjugate
unconjugated
material
colorless
clone
4L9Z4, monoclonal
form
liquid
mol wt
40 kDa
Quality Level
Gene Information
human ... NCF4(4689)
General description
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 240-339 of human NCF4/p40-phox (Q15080).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB, IHC, IP
存储类别
10 - Combustible liquids
wgk
WGK 1
法规信息
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