Anti-β-arrestin1 Antibody, clone F7C2, Rabbit Monoclonal

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human β-arrestin1 (P49407).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

WB