material
colorless
biological source
rabbit
conjugate
unconjugated
clone
6U0G7, monoclonal
form
liquid
mol wt
18 kDa
species reactivity
rat, human, rat
concentration
1.60mg/mL
technique(s)
immunofluorescence: 1:50 - 1:200
western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAEN
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... IL10(3586)
Application
WB, IF/ICC
General description
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IL10 (P22301).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
存储类别
10 - Combustible liquids
wgk
WGK 1
法规信息
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