Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]

A synthetic peptide corresponding to a sequence within amino acids 550-650 of human Neurofilament H (P12036).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

WB, IHC, IF/ICC, IP