Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HDAC6 (Q9UBN7).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

WB, IHC, IP