SAB5702439
Anti-PFKFB3 Antibody, clone 7X10D9, Rabbit Monoclonal
别名:
IPFK2, PFK2, iPFK-2
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关于此项目
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
7X10D9, monoclonal
Application:
IHC, IP, WB
Citations:
-
biological source
rabbit
conjugate
unconjugated
material
colorless
clone
7X10D9, monoclonal
form
liquid
mol wt
60 kDa
Quality Level
Gene Information
human ... PFKFB3(5209)
concentration
1 mg/mL
technique(s)
immunohistochemistry: 1:50 - 1:200, immunoprecipitation (IP): 1:50 - 1:200, western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
LDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFEEHVASTSAALPSCLPPEVPT
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human PFKFB3 (NP_004557.1).
PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Application
WB, IHC, IP
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Skin Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 3
法规信息
常规特殊物品
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