This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]

A synthetic peptide corresponding to a sequence within amino acids 1200-1300 of human NEDD4 (P46934).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

WB