biological source
rabbit
Quality Segment
conjugate
unconjugated
material
colorless
clone
1R5G6, monoclonal
form
liquid
mol wt
60 kDa
species reactivity
human, rat
concentration
0.35 mg/mL
technique(s)
immunoprecipitation (IP): 1:50 - 1:200, western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
EVILLDSDLDEPIDLRCVKTRSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKPPAEAQDEPAESLSEFKPFFGNIIITDVTANCLTVTFKEYVTV
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CBX4(8535)
General description
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 461-560 of human CBX4 (O00257).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB, IP
存储类别
10 - Combustible liquids
wgk
WGK 1