SAB5702661
Anti-CNAP1 Antibody, clone 5E0Q9, Rabbit Monoclonal
别名:
NCAPD2, CAP-D2, CNAP1, hCAP-D2, condensin complex subunit 1
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关于此项目
NACRES:
NA.46
UNSPSC Code:
12352203
Species reactivity:
mouse
Technique(s):
western blot: 1:500 - 1:2000
Application:
WB
Citations:
-
biological source
rabbit
Quality Segment
conjugate
unconjugated
material
colorless
clone
5E0Q9, monoclonal
form
liquid
mol wt
157 kDa
species reactivity
mouse
concentration
1.50 mg/mL
technique(s)
western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
LDDTTLSGSDRNAHLNALKMNCYALIRLLESFETMASQTNLVDLDLGGKGKKARTKAAHGFDWEEERQPILQLLTQLLQLDIRHLWNHSIIEEEFVSLVTG
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CNAP1(9918)
General description
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human CNAP1 (Q15021).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB
存储类别
10 - Combustible liquids
wgk
WGK 1