Anti-KRAS+HRAS+NRAS Antibody

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NRAS (P01111).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

WB, IF/ICC