biological source
rabbit
conjugate
unconjugated
material
colorless
clone
3W5P4, monoclonal
form
liquid
mol wt
43 kDa
species reactivity
rat, human, rat
concentration
1 mg/mL
technique(s)
immunoprecipitation (IP): 1:50 - 1:200
western blot: 1:500 - 1:1000
color
colorless
isotype
IgG
immunogen sequence
LGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CSNK2A2(1459)
Application
WB, IP
General description
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating ′Ser-392′ of p53/TP53 following UV irradiation.
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CSNK2A2 (NP_001887.1).
PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Skin Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 3
法规信息
常规特殊物品
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