Anti-IRF4 Antibody, clone 2U3G10, Rabbit Monoclonal

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IRF4 (Q15306).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

WB