Goat Anti-Mouse IgM(µ chain) Alpaca Heavy chain only Antibody

Goat Anti-Mouse IgM(µ chain) Alpaca Heavy chain only Antibody is designed to specifically detect mouse IgM. It is a monovalent, single domain, recombinant antibody fused to goat IgG Fc. Based on immunoelectrophoresis and/or ELISA, Goat Anti-Mouse IgM(µ chain) Alpaca Heavy chain only Antibody reacts with the µ chain of mouse IgM selectively but not with mouse, rabbit, human, cynomolgus, rat, goat IgG.


Most monoclonal antibodies are generated in mouse. There are five antibody isotypes (IgA, IgD, IgE, IgG, and IgM) from mouse. Each isotype has a different heavy chain. IgM accounts for 5-10% of the immunoglobulin pool and is the predominant antibody in the primary immune response. Unlike IgG, IgM does not contain a hinge region but does contain an additional constant domain. The monomeric form IgM has a molecular weight of 180 KD. It is classically represented as a pentamer of the basic four chain structure held together by a J chain but can also exist in a hexameric form without the J chain and as a monomer on the surface of B-cells.

VHH are single-domain antibodies derived from the variable regions of heavy chain of Camelidae immunoglobulin. The size of VHH is extremely small(less than15KDa) compared to other forms of antibody fragment, which significantly increase the permeability of VHH. Thus VHH is considered of great value for research, diagnostics and therapeutics.

Recombinant Alpaca single variable domain secondary nano antibody

Fc region of mouse IgM (µ chain specific)
Isotype: VHH domain of alpaca IgG2b/2c fused to goat IgG Fc

100 μg in Glass bottle

Lyophilized from 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose

Add 100uL dH2O or 100uL dH2O with 50% Glycerol to a final concentration of 1mg/mL

After reconstitution, store at –20 °C(Avoid freeze / thaw cycles). Stable for 12 months at -20°C

No cross-reactivity with mouse, rabbit, human, cynomolgus, rat, goat IgG