生物来源
alpaca
重组
expressed in HEK 293 cells (Human cell line)
偶联物
unconjugated
抗体形式
affinity purified immunoglobulin
抗体产品类型
secondary antibodies
克隆
recombinant monoclonal
表单
lyophilized solid
分子量
100 kDa
种属反应性
chicken, Alpaca
技术
ELISA: 1:10000-1:50000
western blot: 1:10000-1:50000
尺寸
0.1 mL
颜色
colorless
同位素/亚型
VHH
运输
wet ice
储存温度
2-8°C
一般描述
Goat Anti-Chicken IgY Alpaca Heavy chain only Antibody is designed to specifically detect chicken IgY. It is a monovalent, single domain, recombinant antibody fused to goat IgG Fc. Based on immunoelectrophoresis and/or ELISA, Goat Anti-Chicken IgY Alpaca Heavy chain only Antibody reacts with chicken IgY selectively but not with mouse, rabbit, human, cynomolgus, rat, goat IgG.
Hens egg yolk immunoglobulins IgY can be transferred from the serum of mother hen to the offspring egg yolk to acquire immunity. In the immunodiagnostic technologies, IgY is an excellent antibody for using in immunological assays involving mammalian sera, due to discriminative properties of IgY compared to mammalian IgG, as IgY does not react with the rheumatoid factor and human anti-mouse IgG antibodies do not activate the complement system and do not bind to Fc receptor. Also, they have poor cross reactivity to mammalian IgG due to immunological differences. IgY does not contain a hinge region but does contain an additional constant domain. The whole IgY molecule possesses both the Fc region and the Fab region, which possessing the epitope-recognition site. The IgYcontains two heavy and light chains. The common IgY is monomeric with a molecular weight of approximately 170 kDa.
VHH are single-domain antibodies derived from the variable regions of heavy chain of Camelidae immunoglobulin. The size of VHH is extremely small(less than15KDa) compared to other forms of antibody fragment, which significantly increase the permeability of VHH. Thus VHH is considered of great value for research, diagnostics and therapeutics.
Hens egg yolk immunoglobulins IgY can be transferred from the serum of mother hen to the offspring egg yolk to acquire immunity. In the immunodiagnostic technologies, IgY is an excellent antibody for using in immunological assays involving mammalian sera, due to discriminative properties of IgY compared to mammalian IgG, as IgY does not react with the rheumatoid factor and human anti-mouse IgG antibodies do not activate the complement system and do not bind to Fc receptor. Also, they have poor cross reactivity to mammalian IgG due to immunological differences. IgY does not contain a hinge region but does contain an additional constant domain. The whole IgY molecule possesses both the Fc region and the Fab region, which possessing the epitope-recognition site. The IgYcontains two heavy and light chains. The common IgY is monomeric with a molecular weight of approximately 170 kDa.
VHH are single-domain antibodies derived from the variable regions of heavy chain of Camelidae immunoglobulin. The size of VHH is extremely small(less than15KDa) compared to other forms of antibody fragment, which significantly increase the permeability of VHH. Thus VHH is considered of great value for research, diagnostics and therapeutics.
免疫原
Recombinant Alpaca single variable domain secondary nano antibody
生化/生理作用
Fc region of chicken IgY
Isotype: VHH domain of alpaca IgG2b/2c fused to goat IgG Fc
Isotype: VHH domain of alpaca IgG2b/2c fused to goat IgG Fc
包装
100 μg in Glass bottle
外形
Lyophilized from 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose
制备说明
Add 100uL dH2O or 100uL dH2O with 50% Glycerol to a final concentration of 1mg/mL
After reconstitution, store at –20 °C(Avoid freeze / thaw cycles). Stable for 12 months at -20°C
其他说明
No cross-reactivity with mouse, rabbit, human, cynomolgus, rat, goat IgG
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Warning
危险声明
危险分类
Aquatic Chronic 3 - Skin Sens. 1
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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