SAB6010006
Anti-phospho-MAPT (S214) antibody, clone 31B12, Rabbit Monoclonal
recombinant, expressed in HEK293F cells
别名:
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau), MAPT, MAPTL MTBT1 TAU
重组
expressed in HEK 293 F cells
质量水平
偶联物
unconjugated
抗体产品类型
primary antibodies
克隆
31B12, recombinant monoclonal
表单
liquid
分子量
150 kDa
纯化方式
affinity chromatography
种属反应性
human
浓度
1.5mg/ml
技术
ELISA: 2000:10000
flow cytometry: 1:50-1:200
immunofluorescence: 1:50-1:200
immunohistochemistry: 1:50-1:200
同位素/亚型
IgG
UniProt登记号
运输
wet ice
储存温度
-10 to -25°C
靶向翻译后修饰
phosphorylation (pSer214)
一般描述
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
免疫原
A synthesized peptide derived from Human MAPT
外形
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
制备说明
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
其他说明
RP-pS-LK
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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