SAB6012189
Anti Thiopurine S-Methyltransferase Antibody, clone 24GB1895, Rabbit Monoclonal
clone 24GB1895, recombinant rabbit monoclonal, expressed in HEK293 cells
别名:
TPMTD
生物来源
rabbit (Monoclonal)
质量水平
重组
expressed in HEK 293 cells
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
24GB1895, recombinant monoclonal
表单
buffered aqueous glycerol solution
分子量
28 kDa
种属反应性
rat, human
包装
vial of 1.5 mL
增强验证
recombinant expression
Learn more about Antibody Enhanced Validation
浓度
0.8 mg/ml
技术
flow cytometry: 1:2000
immunofluorescence: 1:100-:1000
western blot: 1:1,000-1:5,000
同位素/亚型
IgG
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运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TPMT(7172)
一般描述
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
免疫原
A synthesized peptide corresponding to a sequence within amino acids 101-125 of human Thiopurine S-methyltransferase [NP_000358.1].
外形
Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
其他说明
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
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