KD-Validated Anti APBB1 Antibody, clone 23GB3665, Rabbit Monoclonal

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer′s disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product′s nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer′s disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

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A synthesized peptide corresponding to a sequence within amino acids 650-710 of human FE65 [NP_001155.1].

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.