KD-Validated Anti Nicastrin Antibody, clone 23GB1040, Rabbit Monoclonal

This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer′s disease; however, the nature of the encoded protein′s role in Alzheimer′s disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]

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A synthesized peptide corresponding to a sequence within amino acids 696-709 of human Nicastrin [NP_056146.1].

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.