产品名称
Glucose-6-phosphate Isomerase human, recombinant, expressed in E. coli
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
specific activity
≥200 units/mg protein
storage temp.
−20°C
Quality Level
相关类别
Biochem/physiol Actions
Glucose-6-phosphate isomerase (GPI) is a homodimeric enzyme ubiquitously present in most organisms. GPI catalyzes the interconversion between glucose-6-phosphate and fructose-6-hosphate, the second step of the glycolytic pathway. In mammals, Glucose-6-phosphate isomerase also acts as an autocrine motility factor (AMF), a neuroleukin, and a maturation factor. GPI deficiency is the second most common erythroenzymopathy of glycolytic enzymes after pyruvate kinase deficiency. Inherited deficiency of the enzymatic activity of GPI causes hereditary nonspherocytic hemolytic anemia (HNSHA) in humans, a severe deficiency that can be associated with hydrops fetalis (a-thalassaemia), immediate neonatal death, and neurological impairment.
General description
C-terminal histidine-tagged
Other Notes
One unit will convert 1.0 mmole of D-fructose 6-phosphate to D-glucose 6-phosphate per inute at pH 7.4 at 25 °C.
Physical form
Supplied as a solution in 50 mM Tris-HCl pH 7.5, and 50% glycerol
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Miao Xu et al.
Blood, 132(6), 622-634 (2018-05-26)
Thrombopoietin (TPO), a hematopoietic growth factor produced predominantly by the liver, is essential for thrombopoiesis. Prevailing theory posits that circulating TPO levels are maintained through its clearance by platelets and megakaryocytes via surface c-Mpl receptor internalization. Interestingly, we found a
Jose Maria Bastida et al.
Thrombosis and haemostasis, 117(1), 66-74 (2016-10-14)
Currently, molecular diagnosis of haemophilia A and B (HA and HB) highlights the excess risk-inhibitor development associated with specific mutations, and enables carrier testing of female relatives and prenatal or preimplantation genetic diagnosis. Molecular testing for HA also helps distinguish
Alice Fabarius et al.
Cancers, 14(12) (2022-06-25)
Soluble factors released from irradiated human mesenchymal stromal cells (MSC) may induce genetic instability in human CD34+ cells, potentially mediating hematologic disorders. Recently, we identified four key proteins in the secretome of X-ray-irradiated MSC, among them three endoplasmic reticulum proteins
Lee-Chun Su et al.
ACS nano, 8(10), 10826-10836 (2014-09-16)
The endothelium monolayer lining in the luminal side of blood vessels provides critical antithrombotic functions. Damage to these cells will expose a highly thrombogenic subendothelium, which leads to pathological vascular changes. Using combined tissue engineering and ligand-receptor targeting strategy, we
Yunmei Wang et al.
Nature communications, 8, 15559-15559 (2017-05-31)
Inflammation and thrombosis occur together in many diseases. The leukocyte integrin Mac-1 (also known as integrin α
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持