form
lyophilized powder
Quality Level
specific activity
≥12 units/mg protein
shipped in
dry ice
storage temp.
−20°C
General description
谷氨酰胺转胺酶(TG)是一系列催化异肽键形成的酶。 这一键合形成发生在谷氨酰胺的γ-羧酰胺基团和各种伯胺（主要是赖氨酸的ε-氨基）之间。 所得谷氨酰胺转胺酶分子间或分子内交联高度稳定，并显示出对蛋白水解降解的高抗性。 谷氨酰胺转胺酶交联活性支持血栓、皮肤和头发的形成。另一方面，TG现在被认为与乳糜泻、亨廷顿和帕金森病有关。历史上，微生物谷氨酰胺转胺酶在食品工业中被大量使用。 与哺乳动物相比，微生物TG分子量小且不依赖钙，因此常被用于较新的应用（如位点特异性蛋白修饰和抗体药物偶联）。
Application
微生物谷氨酰胺转胺酶已被用于：
- 蛋白质交联和特定位点标记
- 抗体药物偶联
- 3D生物打印生物油墨制备
- 食品相关免疫原性/致病性相关研究
Features and Benefits
- 小型(~38kDa)和钙非依赖性酶
- 高度纯化的冻干酶
- 一致和可再现的活性
- 内毒素含量特征化
Preparation Note
仅供研发使用。&不可用于药物、家庭或其他用途。有关危险和安全处理方法的信息，请参阅安全数据说明书。
冷冻干燥后的产品保存在-20°C下。建议将重组蛋白保存在-20°C的工作等分中，以避免反复冻融循环。
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Matthias Torsten et al.
Frontiers in pediatrics, 6, 389-389 (2019-01-09)
The enzyme microbial transglutaminase is heavily used in the food processing industries to ameliorate food qualities and elongate the products' shelf life. As a protein's glue, it cross-links gliadin peptides, creating neo-complexes that are immunogenic and potentially pathogenic to celiac
Istvan Vermes et al.
Movement disorders : official journal of the Movement Disorder Society, 19(10), 1252-1254 (2004-09-16)
Tissue transglutaminase (tTG) is activated during the apoptotic cell death cascade and plays a key role in the formation of apoptotic bodies. We found significant elevation of tTG concentration in the cerebrospinal fluid (CSF) of 54 patients with Parkinson's disease
Martin Griffin et al.
The Biochemical journal, 368(Pt 2), 377-396 (2002-10-09)
Transglutaminases (Tgases) are a widely distributed group of enzymes that catalyse the post-translational modification of proteins by the formation of isopeptide bonds. This occurs either through protein cross-linking via epsilon-(gamma-glutamyl)lysine bonds or through incorporation of primary amines at selected peptide-bound
Miaomiao Zhou et al.
Biofabrication, 11(2), 025011-025011 (2019-02-12)
Gelatin methacryloyl (GelMA) is a versatile biomaterial that has been shown to possess many advantages such as good biocompatibility, support for cell growth, tunable mechanical properties, photocurable capability, and low material cost. Due to these superior properties, much research has
Marcela V Karpuj et al.
Neurochemistry international, 40(1), 31-36 (2001-12-12)
Transglutaminase (TGase) activity is increased in affected regions of brains from patients with Huntington's disease (HD). TGase activity is particularly elevated in the nucleus compared with the cytoplasm from these brains. Gamma-glutaminyl-lysyl cross-links have been detected in nuclear inclusions in
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAE0159-25UN | 04065265095839 |
| SAE0159-250UN | 04065265095822 |
| SAE0159-2000UN | 04065273818215 |
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