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SBR00014

达托霉素二甲基亚砜溶液

Name: 达托霉素二甲基亚砜溶液
Brand: SIGMA

Ready Made Solution, 1 mg/mL in DMSO

别名:

N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine[egr]₁-lactone

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关于此项目

经验公式（希尔记法）:

C₇₂H₁₀₁N₁₇O₂₆

化学文摘社编号:

103060-53-3

分子量:

1620.67

UNSPSC Code:

51102829

NACRES:

NA.76

MDL number:

MFCD28968054

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属性

biological source

Streptomyces roseosporus

Quality Level

200

form

liquid, ready-to-use solution

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

concentration

1 mg/mL in DMSO

color

colorless to faint yellow

antibiotic activity spectrum

Gram-positive bacteria

mode of action

DNA synthesis | interferes, protein synthesis | interferes

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=C(NCC(N[C@H](CCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C)C(N[C@@H](CC(O)=O)C(NC1)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CC(O)=O)NC([C@@H](CC(N)=O)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CCCCCCCCC)=O)=O)=O)=O)[C@@H](C)OC([C@H](CC(C4=C(N)C=CC=C4)=O)NC([C@@]([C@H](C)CC(O)=O)([H])NC(

InChI

1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35?,36-,37?,43+,44+,45+,46+,47+,48+,49+,50-,60+,61?/m1/s1

InChI key

DOAKLVKFURWEDJ-OFNKPWESSA-N

说明

Biochem/physiol Actions

Daptomycin is a natural cyclic lipopeptide antibiotic found in Streptomyces roseosporus. It is has been found to be effective in treating infections caused by aerobic Gram-positive bacteria. Daptomycin inhibits many antibiotic resistant strains such as methicillin-resistant S. aureus (MRSA), vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA).

The mode of action of daptomycin is quite different from that of any other antibiotic. Daptomycin binds to bacterial membranes and causes a rapid depolarization of membrane potential. This loss of membrane potential causes inhibition of protein, DNA, and RNA synthesis, which results in bacterial cell death.

Packaging

0.5ML

Preparation Note

The 1 mg/mL solution may be further diluted in an appropriate buffer prior to use. It is recommended that a fresh dilution be made on the day of use.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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存储类别

10 - Combustible liquids

flash_point_f

188.6 °F

flash_point_c

87 °C

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000224878

0000201435

11161133

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[Daptomycin: revitalizing a former drug due to the need of new active agents against grampositive multiresistant bacterias].

Hernandez Marti V, et al.

Revista Espanola de Quimioterapia : Publicacion Oficial de la Sociedad Espanola de Quimioterapia, 20, 261-276 (2007)

Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids.

He Y, et al.

Bioorganic & Medicinal Chemistry Letters, 22, 6248-6251 (2012)

DptR2, a DeoR-type auto-regulator, is required for daptomycin production in Streptomyces roseosporus.

Feng Wang et al.

Gene, 544(2), 208-215 (2014-04-29)

Daptomycin, a novel cyclic lipopeptide antibiotic against Gram-positive bacteria, is produced by Streptomyces roseosporus. Though its biosynthetic mechanism, structural shuffling and fermentation optimization have been extensively studied, little is understood about its production regulation at the transcriptional levels. Here we

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全球贸易项目编号

货号	GTIN
SBR00014-0.5ML	04061833256213