跳转至内容
Merck
CN

SBR00037

Sigma-Aldrich

Solithromycin

≥98% (HPLC)

别名:

2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, CEM-101, OP-1068

登录查看公司和协议定价

选择尺寸

关于此项目

经验公式（希尔记法）:
C43H65FN6O10
分子量:
845.01
MDL编号:
MFCD30207880
UNSPSC代码:
51102829
NACRES:
NA.76

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

质量水平

200

方案

≥98% (HPLC)

表单

powder

颜色

white to off-white

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

−20°C

SMILES字符串

F[C@@]1(C(=O)O[C@@H]([C@]2(OC(=O)N([C@@H]2[C@H](C(=O)[C@@H](C[C@]([C@@H]([C@H](C1=O)C)O[C@@H]5O[C@@H](C[C@@H]([C@H]5O)N(C)C)C)(OC)C)C)C)CCCC[n]3nnc(c3)c4cc(ccc4)N)C)CC)C

InChI

1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26+,27+,31+,32-,34-,35-,37-,38+,41-,42+,43-/m1/s1

InChI key

IXXFZUPTQVDPPK-ZAWHAJPISA-N

一般描述

Solithromycin is a highly potent next-generation macrolid. the first fluoroketolid. which has potent activity against most macrolide-resistant strains. Solithromycin (CEM-101) is a novel fluoroketolide with improved antimicrobial effectiveness.

应用

Solithromycin has been shown to have potentent activity against S. pneumoniae as well as an extended spectrum of activity against CA-MRS. enterococc according to in vitro and in vivo research. Solithromycin has been used in:

  • the research on the anti-inflammatory effects of macrolides
  • the research of potency of solithromycin in comparison to other antimicrobials
  • in ithe research of the vitro activity of solithromycin against clinical N. gonorrhoeae isolates and reference strain

生化/生理作用

Mode of Action: Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis. Like other ketolide. it should impair bacterial ribosomal subunit formation.

Antimicrobial spectrum: Active against bacteria like Legionella, Chlamydophila, Chlamydia, Mycoplasma, and Ureaplasma and against gonococci and other organisms that cause genitourinary tract infections

特点和优势

High quality antibiotic suitable for mulitple research applications

其他说明

Inxight:Drugs
For additional information on our range of Biochemicals, please complete this form.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000146819
0000146819

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Antimicrobial characterisation of solithromycin (CEM-101), a novel fluoroketolide: activity against staphylococci and enterococci
International Journal of Antimicrobial Agents, 37, 39-45 (2010)
Ward Rodgers et al.
Antimicrobial agents and chemotherapy, 57(4), 1632-1637 (2013-01-16)
The continuing increase in antibiotic-resistant microorganisms is driving the search for new antibiotic targets and improved antimicrobial agents. Ketolides are semisynthetic derivatives of macrolide antibiotics, which are effective against certain resistant organisms. Solithromycin (CEM-101) is a novel fluoroketolide with improved
In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: potential treatment option for gonorrhea?
Golparian et al.
Antimicrobial Agents and Chemotherapy, 56, 2739-2742 (2012)
Yoshiki Kobayashi et al.
The Journal of pharmacology and experimental therapeutics, 345(1), 76-84 (2013-01-30)
Macrolides are reported to reduce exacerbation of chronic inflammatory respiratory disease, such as chronic obstructive pulmonary disease (COPD), and also show anti-inflammatory effects in vitro and in vivo. However the anti-inflammatory efficacies of current macrolides are relatively weak. Here we

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持