SBR00038

Hygromycin B

Name: Hygromycin B
Brand: SIGMA

Min. 95% (HPLC ELSD), from Streptomyces hygroscopicus

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关于此项目

经验公式（希尔记法）:

C₂₀H₃₇N₃O₁₃

CAS Number:

31282-04-9

分子量:

527.52

UNSPSC代码:

51281624

NACRES:

NA.76

主要文件

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Product Name

Hygromycin B, Min. 95% (HPLC ELSD), from Streptomyces hygroscopicus

生物来源

Streptomyces hygroscopicus

质量水平

200

表单

solid

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
fungi
viruses

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

N([C@@H]1[C@H]([C@@H]([C@H]([C@@H](C1)N)O)O[C@@H]2O[C@@H]([C@@H]([C@@H]3O[C@@]4(O[C@@H]32)O[C@@H]([C@@H]([C@@H]([C@H]4O)O)O)[C@H](N)CO)O)CO)O)C

InChI

1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1

InChI key

GRRNUXAQVGOGFE-XKIAHZFYSA-N

一般描述

Chemical structure: aminoglycoside

应用

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.

生化/生理作用

Mode of Action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation.

Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.