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SBR00041

Cefiderocol

Name: Cefiderocol
Brand: SIGMA

别名:

S-649266

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关于此项目

经验公式（希尔记法）:

C₃₀H₃₄ClN₇O₁₀S₂

化学文摘社编号:

1225208-94-5

分子量:

752.21

UNSPSC Code:

12352111

NACRES:

NA.76

MDL number:

MFCD30533432

Assay:

≥95% (HPLC)

Form:

solid

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属性

assay

≥95% (HPLC)

Quality Segment

100

form

solid

reaction suitability

reagent type: chelator

antibiotic activity spectrum

Gram-negative bacteria

mode of action

protein synthesis | inhibits

storage temp.

−20°C

SMILES string

NC1=NC(/C(C(N[C@@H]2C(N3[C@@H]2SCC(C[N+]4(CCCC4)CCNC(C5=CC=C(O)C(O)=C5Cl)=O)=C3C([O-])=O)=O)=O)=N/OC(C(O)=O)(C)C)=CS1

InChI

1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1

InChI key

DBPPRLRVDVJOCL-FQRUVTKNSA-N

说明

General description

Cefiderocol is a novel injectable siderophore cephalosporin, which was formerly known as S-649266. It has a catechol-type siderophore and cephalosporin core and side chains. Cefiderocol has structural similarity with both ceftazidime and cefepime, besides the chlorocatechol group on the end of the C-3 chain.

Cefiderocol has been shown to be effective in preventing the emergence of resistant mutants but is not active against methicillin-resistant Staphylococcus aureus (MRSA) or colistin-resistant bacteria. This versatile compound finds applications in cell biology and biochemical research.

Application

Cefiderocol has been used:

study bacterial infections and tracking their uptake in vivo
the study of the activity of Cefiderocol against gram-negative bacteria

Biochem/physiol Actions

Mode of Action: Cefiderocol binds to specific proteins called penicillin-binding proteins (PBPs) located on the bacterial cell wall. This binding affinity inhibits the synthesis of the bacterial cell wall, leading to cell lysis and bacterial death.

Antimicrobial Spectrum: Cefiderocol has strong antimicrobial properties, especially against a wide spectrum of Gram-negative pathogens. Due to its siderophore core it is also a natural iron-chelator, which adds to its antibacterial activities.

Features and Benefits

High-quality antibiotic suitable for multiple research applications
Ideal for Cell Biology and Biochemical research

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c