SBR00041
Cefiderocol
别名:
S-649266
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经验公式（希尔记法）:
C30H34ClN7O10S2
化学文摘社编号:
分子量:
752.21
UNSPSC Code:
12352111
NACRES:
NA.76
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
assay
≥95% (HPLC)
Quality Segment
form
solid
reaction suitability
reagent type: chelator
antibiotic activity spectrum
Gram-negative bacteria
mode of action
protein synthesis | inhibits
storage temp.
−20°C
SMILES string
NC1=NC(/C(C(N[C@@H]2C(N3[C@@H]2SCC(C[N+]4(CCCC4)CCNC(C5=CC=C(O)C(O)=C5Cl)=O)=C3C([O-])=O)=O)=O)=N/OC(C(O)=O)(C)C)=CS1
InChI
1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1
InChI key
DBPPRLRVDVJOCL-FQRUVTKNSA-N
General description
Cefiderocol has been shown to be effective in preventing the emergence of resistant mutants but is not active against methicillin-resistant Staphylococcus aureus (MRSA) or colistin-resistant bacteria. This versatile compound finds applications in cell biology and biochemical research.
Cefiderocol is a novel injectable siderophore cephalosporin, which was formerly known as S-649266. It has a catechol-type siderophore and cephalosporin core and side chains. Cefiderocol has structural similarity with both ceftazidime and cefepime, besides the chlorocatechol group on the end of the C-3 chain.
Application
Cefiderocol has been used:
- study bacterial infections and tracking their uptake in vivo
- the study of the activity of Cefiderocol against gram-negative bacteria
Biochem/physiol Actions
Mode of Action: Cefiderocol binds to specific proteins called penicillin-binding proteins (PBPs) located on the bacterial cell wall. This binding affinity inhibits the synthesis of the bacterial cell wall, leading to cell lysis and bacterial death.
Antimicrobial Spectrum: Cefiderocol has strong antimicrobial properties, especially against a wide spectrum of Gram-negative pathogens. Due to its siderophore core it is also a natural iron-chelator, which adds to its antibacterial activities.
Antimicrobial Spectrum: Cefiderocol has strong antimicrobial properties, especially against a wide spectrum of Gram-negative pathogens. Due to its siderophore core it is also a natural iron-chelator, which adds to its antibacterial activities.
Features and Benefits
- High-quality antibiotic suitable for multiple research applications
- Ideal for Cell Biology and Biochemical research
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Disclaimer
The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable