InChI
1S/C32H31BrN2O2.C4H4O4/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3;5-3(6)1-2-4(7)8/h4-17,20-21,30,36H,18-19H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t30-,32-;/m1./s1
InChI key
ZLVSPMRFRHMMOY-WWCCMVHESA-N
SMILES string
CN(C)CC[C@@](C1=CC=CC2=CC=CC=C21)([C@H](C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O.C(=C/C(=O)O)\C(=O)O
assay
≥97% (HPLC)
form
powder
color
white to off-white
antibiotic activity spectrum
mycobacteria
mode of action
enzyme | inhibits
Quality Level
General description
Bedaquiline fumarate is an antibioitc with antimycobacterial properties. Bedaquiline fumarate a fumarate salt prepared from equimolar amounts of bedaquiline and fumaric acid. It has a role as an antitubercular agent and an ATP synthase inhibitor.
Application
Bedaquiline Fumarate has also been studied for its potential use in bioluminescence imaging, due to its ability to bind to a reporter protein and enhance its luminescence signal. This has potential applications in a variety of biological research areas, such as protein-protein interactions, drug discovery, and disease modeling.
Biochem/physiol Actions
Bedaquiline Fumarate is an antimycobacterial agent that inhibits mycobacterial ATP synthase, an enzyme essential for energy metabolism in Mycobacterium tuberculosis. Inhibition of ATP synthase disrupts the energy production of the bacteria and leads to their death. Bedaquiline Fumarate is active against mycobacteria.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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