Quality Level
form
liquid, ready-to-use solution
specific activity
Antibacterial
concentration
50 mg/mL in DMSO
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycobacteria, viruses
mode of action
protein synthesis | interferes
storage temp.
−20°C
SMILES string
N5(CCN(CC5)C)\N=C\c1c2c(c3c(c4c(c(c3O)C)O[C@](O\C=C\[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](\C=C\C=C(/C(=O)N2)\C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C)c1O)O
InChI
1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
InChI key
JQXXHWHPUNPDRT-WLSIYKJHSA-N
General description
Rifampicin is a microlide antibiotic effective against gram-positive and gram-negative bacteria, mycobacteria and viruses.
Application
- Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections.
- Rifampicin is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, and primary biliary cirrhosis (PBC).
- Rifampicin was also found active by inhibiting Tau Oligomer Propagation in Alzheimer’s disease.
- Rifampicin is used as a selection agent for agrobacterium mediated plant transformation.
Biochem/physiol Actions
Inhibits the assembly of DNA and protein into mature virus particles.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.
Other Notes
The product is supplied in DMSO at a concentration of 50 mg/mL. Working concentrations for agrobacterium selection are typically 10-50 mg/L.
存储类别
10 - Combustible liquids
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
Specific packaging of custom RNA molecules into cowpea mosaic virus-like particles
Peyret, Hadrien, et al
Methods in Molecular Biology, 103-111 (2022)
Guidelines for the Management of Cholestatic Liver Diseases (2021)
Lu, Lungen
Journal of clinical and translational hepatology (2022)
Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice
Umeda, Tomohiro, et al
Biomedicines, 10.2, 297-297 (2022)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SBR00065-1ML | 04065268864999 |