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Merck
CN

SBR00065

Sigma-Aldrich

Rifampicin Ready Made Solution

50 mg/mL in DMSO

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关于此项目

经验公式（希尔记法）:
C43H58N4O12
化学文摘社编号:
13292-46-1
分子量:
822.94
UNSPSC代码:
41116107
NACRES:
NA.76

主要文件

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表单

liquid
ready-to-use solution

质量水平

200

比活

Antibacterial

浓度

50 mg/mL in DMSO

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
viruses

作用机制

protein synthesis | interferes

储存温度

−20°C

SMILES字符串

N5(CCN(CC5)C)\N=C\c1c2c(c3c(c4c(c(c3O)C)O[C@](O\C=C\[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](\C=C\C=C(/C(=O)N2)\C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C)c1O)O

InChI

1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1

InChI key

JQXXHWHPUNPDRT-WLSIYKJHSA-N

一般描述

Rifampicin is a microlide antibiotic effective against gram-positive and gram-negative bacteria, mycobacteria and viruses.

应用

  • Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections.
  • Rifampicin is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, and primary biliary cirrhosis (PBC).
  • Rifampicin was also found active by inhibiting Tau Oligomer Propagation in Alzheimer’s disease.
  • Rifampicin is used as a selection agent for agrobacterium mediated plant transformation.

生化/生理作用

Inhibits the assembly of DNA and protein into mature virus particles.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.

其他说明

The product is supplied in DMSO at a concentration of 50 mg/mL. Working concentrations for agrobacterium selection are typically 10-50 mg/L.

危险声明

H362

危险分类

Lact.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

188.6 °F - closed cup

闪点(°C)

87 °C - closed cup

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000411085
0000411085
0000345737
0000328305
0000328305

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访问文档库

Guidelines for the Management of Cholestatic Liver Diseases (2021)
Lu, Lungen
Journal of clinical and translational hepatology (2022)
Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice
Umeda, Tomohiro, et al
Biomedicines, 10.2, 297-297 (2022)
Specific packaging of custom RNA molecules into cowpea mosaic virus-like particles
Peyret, Hadrien, et al
Methods in Molecular Biology, 103-111 (2022)
Treatment of rifampicin-resistant tuberculosis disease and infection in children: key updates, challenges and opportunities
Howell, Pauline, et al.
Pathogens (Basel, Switzerland), 11.4, 381-381 (2022)

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