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SBR00077

Dapivirine

Name: Dapivirine
Brand: SIGMA

≥95% (H-NMR), powder

别名:

TMC 120

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关于此项目

经验公式（希尔记法）:

C₂₀H₁₉N₅

化学文摘社编号:

244767-67-7

分子量:

329.40

UNSPSC Code:

51101500

NACRES:

NA.41

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属性

Quality Segment

100

assay

≥95% (H-NMR)

form

powder

color

white to off-white

antibiotic activity spectrum

viruses

mode of action

DNA synthesis | inhibits

storage temp.

2-8°C

SMILES string

CC1=CC(=C(C(=C1)C)NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C

InChI

1S/C20H19N5/c1-13-10-14(2)19(15(3)11-13)24-18-8-9-22-20(25-18)23-17-6-4-16(12-21)5-7-17/h4-11H,1-3H3,(H2,22,23,24,25)

InChI key

ILAYIAGXTHKHNT-UHFFFAOYSA-N

说明

General description

Dapivirine is an antibiotic from a class of nn-nucleoside reverse transcriptase inhibitor compounds. Dapivirine, a substituted diarylpyrimidine derivative, irreversibly binds to and inhibits HIV reverse transcriptase which prevents the conversion of viral RNA to proviral DNA.

Biochem/physiol Actions

Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor and has activity against wild-type virus strains and strains harboring different NNRTI resistance-inducing mutations.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c