InChI
InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)
InChI key
NSQSAUGJQHDYNO-UHFFFAOYSA-N
SMILES string
CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5
assay
≥98% (HPLC)
form
powder
color
white to off-white
mode of action
protein synthesis | inhibits
storage temp.
2-30°C
Quality Level
General description
Tazemetostat is a small molecule inhibitor of the EZH2 protein, which is a histone-lysine N-methyltransferase enzyme that plays a key role in epigenetic regulation of gene expression.
Biochem/physiol Actions
Tazemetostat inhibits the EZH2 protein. EZH2 is a histone-lysine N-methyltransferase enzyme that plays a key role in epigenetic regulation of gene expression in cells. As an epigenetic modifier, EZH2 protein controls the transcriptional repression of various genes involved in cell cycle regulation, DNA repair, and other cellular processes.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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