产品名称
Streptozocin, Ready Made Solution, 20 mg/mL (in citrate buffer (pH=4.5))
InChI
InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
InChI key
ZSJLQEPLLKMAKR-GKHCUFPYSA-N
SMILES string
CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O
biological source
synthetic
assay
≥97% (HPLC)
form
liquid
ready-to-use solution
storage condition
(Light Sensitive)
concentration
20 mg/mL (in citrate buffer (pH=4.5))
color
colorless to yellow
antibiotic activity spectrum
neoplastics
mode of action
DNA synthesis | interferes
shipped in
dry ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Mode of Action: Streptozocin is an N-nitroso-containing compound which acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes.
Antimicrobial Spectrum: Active against a broad spectrum antibiotic activity and antineoplastic properties.
Antimicrobial Spectrum: Active against a broad spectrum antibiotic activity and antineoplastic properties.
Features and Benefits
High quality antibiotic suitable for mulitple research applications
General description
Streptozocin (STZ) found to have two anomers, α and β. STZ is a methylnitrosourea that attached to a glucosamine molecule. As nitrosourea class alkylating agent it results with toxic effect to the cells and cause damage to the DNA.
Application
Streptozocin has been used -
- As an antibiotic4 and antineoplastic agent.
- As a toxic to insulin producing β-cells of pancreas in mammals The relative toxicity to β-cells is occurring because of the similarity of STZ to glucose, as it transported into the cells by glucose transport protein, GLUT2, which is highly expressed on β-cells.
- For treating cancer of Islets of Langerhans and to produce animal models of type 1, diabetes.
- To induce diabetes in rats.It is injected at 60-100mg/Kg to induce diabetes in rats model.
Preparation Note
The solution is light-sensitive and should be used immediately after thawing. Thaw at room temperature; avoid heating.
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