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Merck
CN

SBR00122

Streptozocin

Ready Made Solution, 20 mg/mL (in citrate buffer (pH=4.5))

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关于此项目

经验公式（希尔记法）:
C8H15N3O7
分子量:
265.22
UNSPSC代码:
51101500

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生物来源

synthetic

质量水平

200

方案

≥97% (HPLC)

表单

liquid
ready-to-use solution

储存条件

(Light Sensitive)

浓度

20 mg/mL (in citrate buffer (pH=4.5))

颜色

colorless to yellow

抗生素抗菌谱

neoplastics

作用机制

DNA synthesis | interferes

运输

dry ice

储存温度

−20°C

SMILES字符串

CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O

InChI

InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1

InChI key

ZSJLQEPLLKMAKR-GKHCUFPYSA-N

一般描述

Streptozocin (STZ) found to have two anomers, α and β. STZ is a methylnitrosourea that attached to a glucosamine molecule. As nitrosourea class alkylating agent it results with toxic effect to the cells and cause damage to the DNA.

应用

STZ uses and applications:

  • STZ is an antibiotic4 and antineoplastic agent.
  • STZ is used in the clinic to treat pancreatic cancer.
  • STZ is toxic to insulin producing β-cells of pancreas in mammals The relative toxicity to β-cells is occurring because of the similarity of STZ to glucose, as it transported into the cells by glucose transport protein, GLUT2, which is highly expressed on β-cells.
  • STZ is used for treating cancer of Islets of Langerhans and to produce animal models of type 1, diabetes.
  • STZ is commonly used to induce diabetes in rats. STZ is injected at 60-100mg/Kg to induce diabetes in rats model. -
  • STZ cytotoxicity mechanism study was performed in insulin secreting pancreatic cancer cells (RIN-5F). This study showed maximum inhibition of cell viability (~60-70%) of RIN-5F cells with treatment of STZ at 10mM (~2.67 mg/ml) after 24-48h.

生化/生理作用

Mode of Action: Streptozocin is an N-nitroso-containing compound which acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes.

Antimicrobial Spectrum: Active against a broad spectrum antibiotic activity and antineoplastic properties.

特点和优势

High quality antibiotic suitable for mulitple research applications

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000459211
0000459211

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