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SCP0001

Autocamptide-2 Related Inhibitor Peptide

Name: Autocamptide-2 Related Inhibitor Peptide
Brand: SIGMA

别名:

AIP

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关于此项目

经验公式（希尔记法）:

C₇₈H₁₄₂N₂₂O₂₀

分子量:

1708.10

NACRES:

NA.32

UNSPSC Code:

12352202

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属性

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥70%

storage condition

protect from light

storage temp.

−20°C

说明

Application

Autocamptide-2 Related Inhibitor Peptide (AIP) is highly specific inhibitor of calmodulin-dependent protein kinase II (CaMKII) that may be used to study the role of CaMKII in processes such as heart failure.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

E278078

CR0189

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Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II.

Vassilios J Bezzerides et al.

Circulation, 140(5), 405-419 (2019-06-04)

Catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited cardiac arrhythmia characterized by adrenergically triggered arrhythmias, is inadequately treated by current standard of care. Ca2+/calmodulin-dependent protein kinase II (CaMKII), an adrenergically activated kinase that contributes to arrhythmogenesis in heart disease models, is

CaMKII inhibition in heart failure makes jump to human.

Donald M Bers

Circulation research, 107(9), 1044-1046 (2010-10-30)

Inhibition of calcium-calmodulin-dependent kinase II suppresses cardiac fibroblast proliferation and extracellular matrix secretion.

Wei Zhang et al.

Journal of cardiovascular pharmacology, 55(1), 96-105 (2009-11-26)

Calcium-calmodulin-dependent protein kinase II (CaMKII) is one of the main protein kinases mediating intracellular Ca changes. It is also involved in the process of cardiac diseases, such as cardiac hypertrophy, but its effects on myocardial fibrosis remain unclear. The present

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货号	GTIN
SCP0001-5MG	04061833024485