产品名称
γ Secretase Inhibitor, ≥95% (HPLC)
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥85%
storage condition
protect from light
storage temp.
−20°C
Application
γ Secretase Inhibitor has been used to study the suppressive miR-129 functions through inhibition on estrogen receptor 1 (ESR1) and NOTCH signaling in breast cancer stem cells.
General description
Gamma-secretase is a protein complex containing presenilin, nicastrin, APH-1, and PEN-2. The leupeptin analogue Z-Leu-Leu-Nle-al (N-benzyloxycarbonyl-Leu-Leu-norleucinal; Benzyloxicarbonyl-Leu-Leu-Nle-CHO (LLNle)) and closely related peptides are used as protease and a gamma secretase inhibitors.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Cleonice Michelon et al.
Molecular neurobiology, 57(2), 1159-1169 (2019-11-09)
Inflammatory cytokines are related to impaired learning and memory processes in the central nervous system, contributing to the cognitive dysfunction present in sepsis survivors. In sepsis, brain of survivors presented increased deposition of amyloid-beta (Aβ) peptide and this was associated
MiR-129 blocks estrogen induction of NOTCH signaling activity in breast cancer stem-like cells.
Xiao G, et al.
Oncotarget, 8(61), 103261-103261 (2017)
Tao Na et al.
BMC cancer, 20(1), 1064-1064 (2020-11-06)
Immunomodulatory activities of human mesenchymal stromal /stem cells (hMSCs) has been widely recognized as the most critical function of hMSCs for exerting its therapeutic effects. However, the detailed mechanisms responsible for regulating the immunomodulation of hMSCs still remain largely unknown.
Asha Acharya et al.
PloS one, 6(11), e27743-e27743 (2011-11-24)
Aortic valve calcification is the most common form of valvular heart disease, but the mechanisms of calcific aortic valve disease (CAVD) are unknown. NOTCH1 mutations are associated with aortic valve malformations and adult-onset calcification in families with inherited disease. The
Guodong Xiao et al.
Oncotarget, 8(61), 103261-103273 (2017-12-22)
Stem-like cells in tumor group featured the major role in the chemotherapy resistance of breast cancer, and the reduction of stem-like cells helped to perish the tumor when receiving chemotherapy. Smaller stem cells number indicated better therapeutic effect in vitro
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