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Merck
CN

SCP0020

[Sar1]-Angiotensin II

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关于此项目

经验公式(希尔记法):
C49H71N13O10
分子量:
1002.17
NACRES:
NA.32
UNSPSC Code:
12352209
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assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥65%

storage condition

protect from light

storage temp.

−20°C

Application

Angiotensins are peptide hormone components of the renin-angiotensin system involved in the regulation of blood vessel constriction and aldosterone release. Angiotensin I, a decapeptide derived from angiotensinogen, is a converted to Angiotensin II by the removal of the two C-terminal amino acids. Various analogues of Angiotensins I and II made by amino acid substitution are used in structure and sequence studies to analyze and differentiate the functions of natural angiotensins.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

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Vani X Oliveira et al.
Regulatory peptides, 172(1-3), 1-7 (2011-07-27)
Angiotensin II (AII) is the active octapeptide product of the renin enzymatic cascade, which is responsible for sustaining blood pressure. In an attempt to establish the AII-receptor-bound conformation of this octapeptide, we designed conformationally constrained analogues by scanning the entire
Kar Neng Lai et al.
Contributions to nephrology, 170, 135-144 (2011-06-11)
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in developed countries where type 2 diabetes mellitus has reached epidemic proportions. Although the exact pathogenesis of DN is not fully understood and is likely diverse in nature, there
Novel concept in the mechanism of injury and protection of gastric mucosa: role of Renin-Angiotensin system and active metabolites of Angiotensin.
Brzozowski T, Ptak-Belowska A, et al.
Current Medicinal Chemistry, 16, 55-62 (2012)
Mauricio Sendeski et al.
Radiology, 251(3), 697-704 (2009-04-16)
To determine whether a type of contrast medium (CM), iodixanol, modifies outer medullary descending vasa recta (DVR) vasoreactivity and nitric oxide (NO) production in isolated microperfused DVR. Animal handling conformed to the Animal Care Committee Guidelines of all participating institutions.

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