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Merck
CN

SCP0020

[Sar1]-Angiotensin II

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关于此项目

经验公式(希尔记法):
C49H71N13O10
分子量:
1002.17
NACRES:
NA.32
UNSPSC Code:
12352209
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assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥65%

storage condition

protect from light

storage temp.

−20°C

Application

Angiotensins are peptide hormone components of the renin-angiotensin system involved in the regulation of blood vessel constriction and aldosterone release. Angiotensin I, a decapeptide derived from angiotensinogen, is a converted to Angiotensin II by the removal of the two C-terminal amino acids. Various analogues of Angiotensins I and II made by amino acid substitution are used in structure and sequence studies to analyze and differentiate the functions of natural angiotensins.


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

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Vani X Oliveira et al.
Regulatory peptides, 172(1-3), 1-7 (2011-07-27)
Angiotensin II (AII) is the active octapeptide product of the renin enzymatic cascade, which is responsible for sustaining blood pressure. In an attempt to establish the AII-receptor-bound conformation of this octapeptide, we designed conformationally constrained analogues by scanning the entire
Novel concept in the mechanism of injury and protection of gastric mucosa: role of Renin-Angiotensin system and active metabolites of Angiotensin.
Brzozowski T, Ptak-Belowska A, et al.
Current Medicinal Chemistry, 16, 55-62 (2012)
Kar Neng Lai et al.
Contributions to nephrology, 170, 135-144 (2011-06-11)
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in developed countries where type 2 diabetes mellitus has reached epidemic proportions. Although the exact pathogenesis of DN is not fully understood and is likely diverse in nature, there



全球贸易项目编号

货号GTIN
SCP0020-5MG04061833024614